Multiple Source Phototherapy in Breast Cancer: A Viability Study

A. Lopes, A. Gabriel, J. Machado, P. Ribeiro, R. Gomes, João M. P. Coelho, C. O. Silva, C. P. Reis, J. P. Santos, P. Vieira

Abstract

Radiation therapy is one of many common treatments applied to breast cancer. Most usual radiation sources applied are ionizing radiation, such as g-rays and X-rays, and non-ionizing radiation such as ultraviolet radiation. The possibility of using near infrared light to photoactivate a drug inside an 8 cm diameter biological object is discussed in this work via Monte Carlo simulations. Two simulation setups performed in the Geant4/GAMOS framework are presented in order to study the viability of photoactivating a drug by using several near infrared light sources. The overall objective of this technique is to minimize energy concentrated at objects surface and maximize it in a predefined region of interest. Results show an increase energy absorption in the desired region of interest inside a 8 cm object, when a higher absorption particle is present. With the use of multiple sources it is possible to photoactivate the drug while causing minimal damage to the surface of the radiated object.

References

  1. Bashkatov, A. N., Genina, E. A., Kochubey, V. I., and Tuchin, V. V. (2005). Optical properties of human skin, subcutaneous and mucous tissues in the wavelength range from 400 to 2000nm. Journal of Physics D: Applied Physics, 38(15):2543.
  2. Bohren, C. F. and Huffman, D. R. (2007). Appendix A: Homogeneous Sphere, pages 477-482. Wiley-VCH Verlag GmbH.
  3. Costa, M. M., Silva, S., and et al. (2014). Phototherapy 660 nm for the prevention of radiodermatitis in breast cancer patients receiving radiation therapy: study protocol for a randomized controlled trial. BioMed Central, 15.
  4. Gabriel, A., Machado, J., Gomes, R., Coelho, J., Silva, C., Reis, C., Santos, J., and Vieira, P. (2015). Concentrated photoactivation: focusing light through scattering. In World Congress on Medical Physics and Biomedical Engineering, June 7-12, 2015, Toronto, Canada, volume 51, pages 1727-1730, Toronto, Canada.
  5. Gaigalas, A. K., He, H.-J., and Wang, L. (2009). Measurement of absorption and scattering with an integrating sphere detector: Application to microalgae. Journal of Research of the National Institute of Standards and Technology, 114(2):69.
  6. Gibson, A. P., Hebden, J. C., and Arridge, S. R. (2005). Recent advances in diffuse optical imaging. Physics in Medicine and Biology, 50(4).
  7. Glaser, A. K., Kanick, S. C., Zhang, R., Arce, P., and Pogue, B. W. (2013). A gamos plug-in for geant4 based monte carlo simulation of radiation-induced light transport in biological media. Optical Society of America, 4(5):741-759.
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Paper Citation


in Harvard Style

Lopes A., Gabriel A., Machado J., Ribeiro P., Gomes R., Coelho J., Silva C., Reis C., Santos J. and Vieira P. (2016). Multiple Source Phototherapy in Breast Cancer: A Viability Study . In Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, (BIOSTEC 2016) ISBN 978-989-758-170-0, pages 247-250. DOI: 10.5220/0005794902470250


in Bibtex Style

@conference{biodevices16,
author={A. Lopes and A. Gabriel and J. Machado and P. Ribeiro and R. Gomes and João M. P. Coelho and C. O. Silva and C. P. Reis and J. P. Santos and P. Vieira},
title={Multiple Source Phototherapy in Breast Cancer: A Viability Study},
booktitle={Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, (BIOSTEC 2016)},
year={2016},
pages={247-250},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0005794902470250},
isbn={978-989-758-170-0},
}


in EndNote Style

TY - CONF
JO - Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, (BIOSTEC 2016)
TI - Multiple Source Phototherapy in Breast Cancer: A Viability Study
SN - 978-989-758-170-0
AU - Lopes A.
AU - Gabriel A.
AU - Machado J.
AU - Ribeiro P.
AU - Gomes R.
AU - Coelho J.
AU - Silva C.
AU - Reis C.
AU - Santos J.
AU - Vieira P.
PY - 2016
SP - 247
EP - 250
DO - 10.5220/0005794902470250