An Impedance Spectroscopy ASIC for Low-Frequency Characterization of Biological Samples

Juan J. Montero-Rodríguez, Edgar Eduardo Salazar-Flórez, Paola Vega-Castillo, Jakob M. Tomasik, Wjatscheslaw Galjan, Kristian M. Hafkemeyer, Wolfgang Krautschneider

2016

Abstract

This paper describes the design and testing of an ASIC for impedance spectroscopy of biological samples at frequencies up to 40 kHz. The circuit is designed in the 350 nm AMS H35B4 technology and enables the measurement of impedances in the range of 10 kW up to 28 MW. The design features a digital oscillator and a current-to-voltage converter. The ASIC is used to monitor the growth of yeast cell cultures and porcine chondrocytes, in real-time, using a standard 384-well plate and copper electrodes.

References

  1. Alvarenga, R. L. and Souza, M. N. (2007). Estimation of the Lactate Threshold Using Bioelectrical Impedance Spectroscopy: A New Noninvasive Method. In 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, volume 2007, pages 3052-3055. IEEE.
  2. Asami, K., Gheorghiu, E., and Yonezawa, T. (1999). Real-Time Monitoring of Yeast Cell Division by Dielectric Spectroscopy. Biophysical Journal, 76(6):3345-3348.
  3. Giaever, I. and Keese, C. R. (1984). Monitoring fibroblast behavior in tissue culture with an applied electric field. Proceedings of the National Academy of Sciences, 81(12):3761-3764.
  4. Giaever, I. and Keese, C. R. (1986). Use of Electric Fields to Monitor the Dynamical Aspect of Cell Behavior in Tissue Culture. IEEE Transactions on Biomedical Engineering, BME-33(2):242-247.
  5. Hossain, Q. D. and Dhar, S. K. (2013). Characterization of Physiological Glucose Concentration Using Electrical Impedance Spectroscopy. International Journal of Computer Science, 10(1):105-111.
  6. Keysight (2015). Impedance Measurement Handbook. Keysight Technologies, https://www.keysight.com/, 4th edition.
  7. Lu, A. and Roberts, G. (1994). A High-Quality Analog Oscillator Using Oversampling D/A Conversion Techniques. IEEE Transactions on Circuits and Systems, 41(7):437-444.
Download


Paper Citation


in Harvard Style

Montero-Rodríguez J., Salazar-Flórez E., Vega-Castillo P., Tomasik J., Galjan W., Hafkemeyer K. and Krautschneider W. (2016). An Impedance Spectroscopy ASIC for Low-Frequency Characterization of Biological Samples . In Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, (BIOSTEC 2016) ISBN 978-989-758-170-0, pages 222-228. DOI: 10.5220/0005772202220228


in Bibtex Style

@conference{biodevices16,
author={Juan J. Montero-Rodríguez and Edgar Eduardo Salazar-Flórez and Paola Vega-Castillo and Jakob M. Tomasik and Wjatscheslaw Galjan and Kristian M. Hafkemeyer and Wolfgang Krautschneider},
title={An Impedance Spectroscopy ASIC for Low-Frequency Characterization of Biological Samples},
booktitle={Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, (BIOSTEC 2016)},
year={2016},
pages={222-228},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0005772202220228},
isbn={978-989-758-170-0},
}


in EndNote Style

TY - CONF
JO - Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, (BIOSTEC 2016)
TI - An Impedance Spectroscopy ASIC for Low-Frequency Characterization of Biological Samples
SN - 978-989-758-170-0
AU - Montero-Rodríguez J.
AU - Salazar-Flórez E.
AU - Vega-Castillo P.
AU - Tomasik J.
AU - Galjan W.
AU - Hafkemeyer K.
AU - Krautschneider W.
PY - 2016
SP - 222
EP - 228
DO - 10.5220/0005772202220228