A Targeting Self-breakable Agent for Increased Efficacy of Chemotherapeutic Drugs against Caco2 Cells

Ming-Hsien Tsai, Ming-Jium Shieh, Cheng-Liang Peng

Abstract

Many types of nano-sized anti-cancer agents that could increase efficacy of chemotherapeutic drugs have been created and developed in colon cancer treatment over years. Moreover, with the intention of achieving the ideal chemotherapeutic efficacy, nano-sized anti-cancer agents were further designed to have specific functions, efficiently killing colon cancer cells. Our research team focused on two important functions in designing nano-sized agents, controlled drug release and targeting functions. Thus, targeting functional micelles which entrapped chemotherapeutic drug, 7-ethyl-10-hydroxy-camptothecin (SN38) were designed in nano-size and possessed disulfide bonds in this study. In particular, Self-Breakable SN38-loaded micelles (SN/38 micelles), Non-Breakable micelles SN38-loaded (NB/38 micelles) and Folate-targeting Self- Breakable SN38-loaded micelles (FSB/38 micelles) were prepared and tested to the designed agents. The results showed that the folate-decorated functional micelles with disulfide bonds could be an effective chemotherapeutic agent for colon cancer treatment.

References

  1. Bala, V., Rao, S., Boyd, B. J. & Prestidge, C. A. 2013. Prodrug And Nanomedicine Approaches For The Delivery Of The Camptothecin Analogue Sn38. J Control Release, 172, 48-61.
  2. Chen, Y.-I., Peng, C.-L., Lee, P.-C., Tsai, M.-H., Lin, C.- Y., Shih, Y.-H., Wei, M.-F., Luo, T.-Y. & Shieh, M.-J. 2015. Traceable Self-Assembly Of Laser-Triggered Cyanine-Based Micelle For Synergistic Therapeutic Effect. Advanced Healthcare Materials, 4, 892-902.
  3. Cuong, N.-V., Li, Y.-L. & Hsieh, M.-F. 2012. Targeted Delivery Of Doxorubicin To Human Breast Cancers By Folate-Decorated Star-Shaped Peg-Pcl Micelle. Journal Of Materials Chemistry, 22, 1006-1020.
  4. Estrella, V., Chen, T., Lloyd, M., Wojtkowiak, J., Cornnell, H. H., Ibrahim-Hashim, A., Bailey, K., Balagurunathan, Y., Rothberg, J. M., Sloane, B. F., Johnson, J., Gatenby, R. A. & Gillies, R. J. 2013. Acidity Generated By The Tumor Microenvironment Drives Local Invasion. Cancer Research, 73, 1524- 1535.
  5. Huo, M., Yuan, J., Tao, L. & Wei, Y. 2014. RedoxResponsive Polymers For Drug Delivery: From Molecular Design To Applications. Polymer Chemistry, 5, 1519-1528.
  6. Joralemon, M. J., Mcrae, S. & Emrick, T. 2010. Pegylated Polymers For Medicine: From Conjugation To SelfAssembled Systems. Chemical Communications, 46, 1377-1393.
  7. Kawato, Y., Aonuma, M., Hirota, Y., Kuga, H. & Sato, K. 1991. Intracellular Roles Of Sn-38, A Metabolite Of The Camptothecin Derivative Cpt-11, In The Antitumor Effect Of Cpt-11. Cancer Research, 51, 4187-4191.
  8. Khatik, R., Dwivedi, P., Junnuthula, V. R., Sharma, K., Chuttani, K., Mishra, A. K. & Dwivedi, A. K. 2015. Potential In Vitro And In Vivo Colon Specific Anticancer Activity In A Hct-116 Xenograft Nude Mice Model: Targeted Delivery Using Enteric Coated Folate Modified Nanoparticles. Rsc Advances, 5, 16507-16520.
  9. Lai, T. C., Cho, H. & Kwon, G. S. 2014. Reversibly Core Cross-Linked Polymeric Micelles With Ph- And Reduction-Sensitivities: Effects Of Cross-Linking Degree On Particle Stability, Drug Release Kinetics, And Anti-Tumor Efficacy. Polymer Chemistry, 5, 1650-1661.
  10. Peng, C.-L., Shih, Y.-H., Lee, P.-C., Hsieh, T. M.-H., Luo, T.-Y. & Shieh, M.-J. 2011a. Multimodal ImageGuided Photothermal Therapy Mediated By 188reLabeled Micelles Containing A Cyanine-Type Photosensitizer. Acs Nano, 5, 5594-5607.
  11. Peng, C. L., Shieh, M. J., Tsai, M. H., Chang, C. C. & Lai, P. S. 2008. Self-Assembled Star-Shaped Chlorin-Core Poly(Epsilon-Caprolactone)-Poly(Ethylene Glycol) Diblock Copolymer Micelles For Dual ChemoPhotodynamic Therapies. Biomaterials, 29, 3599-608.
  12. Peng, C. L., Tsai, H. M., Yang, S. J., Luo, T. Y., Lin, C. F., Lin, W. J. & Shieh, M. J. 2011b. Development Of Thermosensitive Poly(N-Isopropylacrylamide-Co-((2- Dimethylamino) Ethyl Methacrylate))-Based Nanoparticles For Controlled Drug Release. Nanotechnology, 22, 265608.
  13. Peng, C. L., Yang, L. Y., Luo, T. Y., Lai, P. S., Yang, S. J., Lin, W. J. & Shieh, M. J. 2010. Development Of Ph Sensitive 2-(Diisopropylamino)Ethyl Methacrylate Based Nanoparticles For Photodynamic Therapy. Nanotechnology, 21, 155103.
  14. Sinn Aw, M., Kurian, M. & Losic, D. 2014. Non-Eroding Drug-Releasing Implants With Ordered Nanoporous And Nanotubular Structures: Concepts For Controlling Drug Release. Biomaterials Science, 2, 10-34.
  15. Vaupel, P., Kallinowski, F. & Okunieff, P. 1989. Blood Flow, Oxygen And Nutrient Supply, And Metabolic Microenvironment Of Human Tumors: A Review. Cancer Research, 49, 6449-6465.
  16. Xing, Q., Li, N., Jiao, Y., Chen, D., Xu, J., Xu, Q. & Lu, J. 2015. Near-Infrared Light-Controlled Drug Release And Cancer Therapy With Polymer-Caged Upconversion Nanoparticles. Rsc Advances, 5, 5269- 5276.
  17. Xu, S., Olenyuk, B. Z., Okamoto, C. T. & Hamm-Alvarez, S. F. 2013. Targeting Receptor-Mediated Endocytotic Pathways With Nanoparticles: Rationale And Advances. Adv Drug Deliv Rev, 65, 121-38.
Download


Paper Citation


in Harvard Style

Tsai M., Shieh M. and Peng C. (2016). A Targeting Self-breakable Agent for Increased Efficacy of Chemotherapeutic Drugs against Caco2 Cells . In Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, (BIOSTEC 2016) ISBN 978-989-758-170-0, pages 216-221. DOI: 10.5220/0005766002160221


in Bibtex Style

@conference{biodevices16,
author={Ming-Hsien Tsai and Ming-Jium Shieh and Cheng-Liang Peng},
title={A Targeting Self-breakable Agent for Increased Efficacy of Chemotherapeutic Drugs against Caco2 Cells},
booktitle={Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, (BIOSTEC 2016)},
year={2016},
pages={216-221},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0005766002160221},
isbn={978-989-758-170-0},
}


in EndNote Style

TY - CONF
JO - Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, (BIOSTEC 2016)
TI - A Targeting Self-breakable Agent for Increased Efficacy of Chemotherapeutic Drugs against Caco2 Cells
SN - 978-989-758-170-0
AU - Tsai M.
AU - Shieh M.
AU - Peng C.
PY - 2016
SP - 216
EP - 221
DO - 10.5220/0005766002160221