Spectral and Lifetime Measurements of the Endogenous Fluorescence Variation of Freshly Resected Human Samples over Time - Measuring Endogenous Fluorescence Changes at Different Moment after Tumor or Epileptic Cortex Excision

M. Zanello, A. Ibrahim, F. Poulon, P. Varlet, B. Devaux, D. Abi Haidar

Abstract

Analysis of human tissue endogenous fluorescence is becoming a new modality of medical imaging. Its capacities represent the missing link between macroscopic radiological tools such as MRI and CT-scan and the surgeon view during surgical procedures. However, numerous aspects of this signal are not well known. Time dependence is one of these aspects. The aim of this work is to investigate the autofluorescence changes with time. Five ex vivo human samples were studied. Spectral and lifetime measurements were acquired each hour. Fluorescence intensity decreased slightly with time. This decrease existed for healthy and tumoral samples and did not affect the differences between them: higher fluorescence intensity for control samples compared to tumor samples. Lifetime values showed a slight decrease too for both type of tissue. This work is the first report of fresh human brain samples multimodal autofluorescence analysis with time.

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Paper Citation


in Harvard Style

Zanello M., Ibrahim A., Poulon F., Varlet P., Devaux B. and Abi Haidar D. (2016). Spectral and Lifetime Measurements of the Endogenous Fluorescence Variation of Freshly Resected Human Samples over Time - Measuring Endogenous Fluorescence Changes at Different Moment after Tumor or Epileptic Cortex Excision . In Proceedings of the 4th International Conference on Photonics, Optics and Laser Technology - Volume 1: PHOTOPTICS, ISBN 978-989-758-174-8, pages 13-17. DOI: 10.5220/0005654900130017


in Bibtex Style

@conference{photoptics16,
author={M. Zanello and A. Ibrahim and F. Poulon and P. Varlet and B. Devaux and D. Abi Haidar},
title={Spectral and Lifetime Measurements of the Endogenous Fluorescence Variation of Freshly Resected Human Samples over Time - Measuring Endogenous Fluorescence Changes at Different Moment after Tumor or Epileptic Cortex Excision},
booktitle={Proceedings of the 4th International Conference on Photonics, Optics and Laser Technology - Volume 1: PHOTOPTICS,},
year={2016},
pages={13-17},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0005654900130017},
isbn={978-989-758-174-8},
}


in EndNote Style

TY - CONF
JO - Proceedings of the 4th International Conference on Photonics, Optics and Laser Technology - Volume 1: PHOTOPTICS,
TI - Spectral and Lifetime Measurements of the Endogenous Fluorescence Variation of Freshly Resected Human Samples over Time - Measuring Endogenous Fluorescence Changes at Different Moment after Tumor or Epileptic Cortex Excision
SN - 978-989-758-174-8
AU - Zanello M.
AU - Ibrahim A.
AU - Poulon F.
AU - Varlet P.
AU - Devaux B.
AU - Abi Haidar D.
PY - 2016
SP - 13
EP - 17
DO - 10.5220/0005654900130017