Impact of Pericardial Effusion on Cardiac Mechanics in Patients with Dilated Cardiomyopathy

Francesco Scardulla, Antonino Rinaudo, Cesare Scardulla, Salvatore Pasta

2013

Abstract

Dilated cardiomyopathy (CDM) is a degenerative disease of the myocardium accompanied by left ventricular (LV) remodeling, resulting in an impaired pump performance. Differently, pericardial effusion (PE) is a liquid accumulation in the pericardial cavity, which may inhibit blood filling of heart chambers. Clinical evidence show that PE may improve pump performance in patients with CDM. Therefore, this study aims to assess wall stress and global function of patients with CDM, PE as compared to healthy patient. These findings suggests that CDM has an important implication in the mechanical changes of LV and right ventricle by increasing wall stress and reducing pump function. Conversely, PE determines lowering myocardial fiber stress and improves global function as compared to those of CDM.

References

  1. Carrick, R., Ge, L., Lee, L. C., Zhang, Z., Mishra, R., Axel, L., Guccione, J. M., Grossi, E. A., Ratcliffe, M. B., 2012. Patient-specific finite element-based analysis of ventricular myofiber stress after Coapsys: importance of residual stress. Ann Thorac Surg 93:1964-1971.
  2. Cohn, J. N., Ferrari, R., Sharpe, N., 2000. Cardiac remodeling--concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling. J Am Coll Cardiol 35:569- 582.
  3. Frohlich, G. M., Keller, P., Schmid, F., Wolfrum, M., Osranek, M., Falk, C., Noll, G., Enseleit, F., Reinthaler, M., Meier, P., Luscher, T. F., Ruschitzka, F., Tanner, F. C., 2013. Haemodynamically irrelevant pericardial effusion is associated with increased mortality in patients with chronic heart failure. Eur Heart J
  4. Guccione, J. M., Moonly, S. M., Moustakidis, P., Costa, K. D., Moulton, M. J., Ratcliffe, M. B., Pasque, M. K., 2001. Mechanism underlying mechanical dysfunction in the border zone of left ventricular aneurysm: a finite element model study. Ann Thorac Surg 71:654-662.
  5. Hayashida, W., Kumada, T., Nohara, R., Tanio, H., Kambayashi, M., Ishikawa, N., Nakamura, Y., Himura, Y., Kawai, C., 1990. Left ventricular regional wall stress in dilated cardiomyopathy. Circulation 82:2075-2083.
  6. Jhun, C. S., Wenk, J. F., Zhang, Z., Wall, S. T., Sun, K., Sabbah, H. N., Ratcliffe, M. B., Guccione, J. M., 2010. Effect of adjustable passive constraint on the failing left ventricle: a finite-element model study. Ann Thorac Surg 89:132-137.
  7. McCulloch, A., Waldman, L., Rogers, J., Guccione, J., 1992. Large-scale finite element analysis of the beating heart. Crit Rev Biomed Eng 20:427-449.
  8. Mirhosseini, S. M., Fakhri, M., Mozaffary, A., Lotfaliany, M., Behzadnia, N., Ansari Aval, Z., Ghiasi, S. M., Boloursaz, M. R., Masjedi, M. R., 2013. Risk factors affecting the survival rate in patients with symptomatic pericardial effusion undergoing surgical intervention. Interact Cardiovasc Thorac Surg 16:495- 500.
  9. Nakayama, Y., Shimizu, G., Hirota, Y., Saito, T., Kino, M., Kitaura, Y., Kawamura, K., 1987. Functional and histopathologic correlation in patients with dilated cardiomyopathy: an integrated evaluation by multivariate analysis. J Am Coll Cardiol 10:186-192.
  10. Omens, J. H., MacKenna, D. A., McCulloch, A. D., 1993. Measurement of strain and analysis of stress in resting rat left ventricular myocardium. J Biomech 26:665- 676.
  11. Quarterman, R. L., Moonly, S., Wallace, A. W., Guccione, J., Ratcliffe, M. B., 2002. A finite element model of left ventricular cellular transplantation in dilated cardiomyopathy. ASAIO J 48:508-513.
  12. Ratcliffe, M. B., Hong, J., Salahieh, A., Ruch, S., Wallace, A. W., 1998. The effect of ventricular volume reduction surgery in the dilated, poorly contractile left ventricle: a simple finite element analysis. J Thorac Cardiovasc Surg 116:566-577.
  13. Swynghedauw, B., 1999. Molecular mechanisms of myocardial remodeling. Physiol Rev 79:215-262.
  14. Vetter, F. J., McCulloch, A. D., 2000. Three-dimensional stress and strain in passive rabbit left ventricle: A model study. Ann Biomed Eng 28:781-792.
  15. Walker, J. C., Ratcliffe, M. B., Zhang, P., Wallace, A. W., Fata, B., Hsu, E. W., Saloner, D., Guccione, J. M., 2005. MRI-based finite-element analysis of left ventricular aneurysm. Am J Physiol-Heart C 289:H692-H700.
  16. Wall, S. T., Walker, J. C., Healy, K. E., Ratcliffe, M. B., Guccione, J. M., 2006. Theoretical impact of the injection of material into the myocardium - A finite element model simulation. Circulation 114:2627-2635.
  17. Wenk, J., Jhun, C.-S., Sun, K., Ratcliffe, M., Guccione, J., 2010. Surgical Left Ventricular Remodeling Procedures, in: Guccione, J. M., Kassab, G. S., Ratcliffe, M. B. (Eds.), Computational Cardiovascular Mechanics. Springer US, pp. 197-210.
  18. Zhong, L., Su, Y., Yeo, S. Y., Tan, R. S., Ghista, D. N., Kassab, G., 2009. Left ventricular regional wall curvedness and wall stress in patients with ischemic dilated cardiomyopathy. Am J Physiol Heart Circ Physiol 296:H573-584.
Download


Paper Citation


in Harvard Style

Scardulla F., Rinaudo A., Scardulla C. and Pasta S. (2013). Impact of Pericardial Effusion on Cardiac Mechanics in Patients with Dilated Cardiomyopathy . In Proceedings of the 3rd International Conference on Simulation and Modeling Methodologies, Technologies and Applications - Volume 1: BIOMED, (SIMULTECH 2013) ISBN 978-989-8565-69-3, pages 639-644. DOI: 10.5220/0004615906390644


in Bibtex Style

@conference{biomed13,
author={Francesco Scardulla and Antonino Rinaudo and Cesare Scardulla and Salvatore Pasta},
title={Impact of Pericardial Effusion on Cardiac Mechanics in Patients with Dilated Cardiomyopathy},
booktitle={Proceedings of the 3rd International Conference on Simulation and Modeling Methodologies, Technologies and Applications - Volume 1: BIOMED, (SIMULTECH 2013)},
year={2013},
pages={639-644},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004615906390644},
isbn={978-989-8565-69-3},
}


in EndNote Style

TY - CONF
JO - Proceedings of the 3rd International Conference on Simulation and Modeling Methodologies, Technologies and Applications - Volume 1: BIOMED, (SIMULTECH 2013)
TI - Impact of Pericardial Effusion on Cardiac Mechanics in Patients with Dilated Cardiomyopathy
SN - 978-989-8565-69-3
AU - Scardulla F.
AU - Rinaudo A.
AU - Scardulla C.
AU - Pasta S.
PY - 2013
SP - 639
EP - 644
DO - 10.5220/0004615906390644