Authors:
Seda Aslan
1
;
Xiaolong Liu
2
;
Enze Chen
3
;
Miya Mese-Jones
4
;
Bryan Gonzalez
5
;
Ryan O’Hara
5
;
Yue-Hin Loke
6
;
5
;
Narutoshi Hibino
7
;
Laura Olivieri
8
;
Axel Krieger
1
and
Thao Nguyen
1
Affiliations:
1
Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, U.S.A.
;
2
Department of Mechanical Engineering, Texas Tech University, Lubbock, TX, U.S.A.
;
3
Department of Civil and Systems Engineering, Johns University, Baltimore, MD, U.S.A.
;
4
Baltimore Polytechnic Institute, Baltimore, MD, U.S.A.
;
5
Sheikh Zayed Institute of Pediatric Surgical Innovation, Children’s National Hospital, Washington DC, U.S.A.
;
6
Division of Cardiology, Children’s National Hospital, Washington DC, U.S.A.
;
7
Section of Cardiac Surgery, Department of Surgery, The University of Chicago Medicine, Chicago, IL, U.S.A.
;
8
Division of Pediatric Cardiology, University of Pittsburgh Medical Center, Pittsburgh, PA, U.S.A.
Keyword(s):
Biomechanical Modeling, Arterial Wall Modeling, Patient-Specific FE Models.
Abstract:
Computational models have been instrumental in advancing cardiovascular applications, particularly in simulating arterial behaviors for pre-surgical treatment strategies. Nonetheless, uncertainties arising from patient-specific parameters, such as arterial wall thickness and material properties, pose challenges to their precision. This study utilized finite element analysis to simulate the deformation response of the porcine pulmonary artery to a pressure change and performed a sensitivity analysis of the effects of material properties and vessel wall thickness on the deformation. The widely recognized Holzapfel-Gasser-Ogden (HGO) model was used to describe the stress-strain behavior of the arterial wall. Initially, the arterial walls were modeled as a single layer, then as separate adventitia and intima-media layers with constant thickness. The model complexity was increased by varying thickness and specific material properties of different regions in pulmonary arteries, based on ex
vivo data from existing literature. For the sensitivity analysis, the HGO model parameters were adjusted within their measured variance to study their impact on deformation. The results showed that a single layer, regionally varying wall thickness is needed to reproduce the in vivo measure strain response of the cardiac cycle. The strain response was also most sensitive to variations in the thickness and isotropic shear modulus of the vessel wall. Using this knowledge, we tuned the model parameters for three porcine models until the deformation results were within 10% of the MRI-measured deformations. This study offers valuable insights to identify key model features for specimen-specific computational modeling of the pulmonary artery, thus providing a foundation for enhancing the realism of soft tissue deformation simulations.
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