Authors:
Clara M. Ionescu
1
;
Dana Copot
1
;
Hannes Maes
2
;
Gerd Vandersteen
2
;
Amélie Chevalier
1
and
Robin De Keyser
1
Affiliations:
1
Ghent University, Belgium
;
2
Vrije Universiteit Brussel, Belgium
Keyword(s):
Respiratory Impedance, Frequency Response, Nonlinear System, Detection Lines, Spectral Analysis, Forced Ocillation Technique.
Related
Ontology
Subjects/Areas/Topics:
Applications and Services
;
Biomedical Engineering
;
Biomedical Signal Processing
;
Computer Vision, Visualization and Computer Graphics
;
Detection and Identification
;
Medical Image Detection, Acquisition, Analysis and Processing
Abstract:
This paper describes the nonlinear effects in the respiratory signals captured by means of the forced oscillation
technique (FOT) non-invasive lung function tests. The measurements are performed using a prototype device
developed such that it overcomes the limitations present in commercial FOT devices and allows the generation
of multisine signals below 4 Hz. The principle of sending detection lines in the frequency domain for characterizing
odd and even nonlinear contributions from a nonlinear system are introduced briefly to the reader.
Two detection methods are presented: a robust method based on multiple measurements and a fast method
based on a single measurement. The ingenious combination of the device and the method allow to detect the
nonlinear contributions in the respiratory signals: pressure and flow. The intrinsicly pesent nonlinear effects
are quantified by means of a novel index and analyzed in two groups of healthy volunteers, aged 14 years and
aged 17 years, respectiv
ely. The results we obtain suggest that the proposed device, method and index are a
successful combination of lung function testing, signal processing and classification items.
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