Authors:
Andreas Bahr
;
Lait Abu Saleh
;
Dietmar Schroeder
and
Wolfgang Krautschneider
Affiliation:
Hamburg University of Technology, Germany
Keyword(s):
Biomedical Signal Acquisition, Neural Recording, Integrated Circuit, Mixed-signal Integrated Circuit, Error Correction Code, 130nm CMOS Technology, SPI Interface.
Related
Ontology
Subjects/Areas/Topics:
Biomedical Engineering
;
Biomedical Instrumentation
;
Biomedical Instruments and Devices
Abstract:
In the research of neural diseases like epilepsy and schizophrenia genetic mouse models play a very important role. Dysfunctions during early brain development might cause these diseases. The analysis of the brain signals is the key to understand this process and develop treatments. To enable the acquisition of brain signals from neonatal mice, an integrated circuit for neural recording is presented. It is minimized for low area consumption and can be placed in a miniaturized system on the head of the mouse. It is intended to acquire the local field and action potentials from the brain. 16 analog input channels are implemented. The biomedical signals are amplified with analog pre-amplifiers. Two parallel structures of 8:1 multiplexer, post-amplifier and ADC are implemented to digitize the signals. The post-amplifier has programmable gain and high driving capability. The ADC is implemented as a 10 bit SAR ADC. Digital SPI interfacing is used to reduce the number of transmission lines.
Reed Solomon Error Correction Coding has been implemented to enable error correction. The mixed-signal integrated circuit has been successfully implemented in a 130 nm CMOS technology. It is optimized for low area consumption; the channel density is approximately 10 channels/mm².
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