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Authors: Hye-Lyn Lee ; Suk-Heung Song ; Hee-Taek Lim ; Hyung-Joon Kim ; Min-Suk Park and Hyo-Il Jung

Affiliation: Yonsei University, Korea, Republic of

Keyword(s): Multi-layered microfluidic channel, Magnetophoretic cell separation, Microelectromagnet, Microbeads, Magnetic field.

Related Ontology Subjects/Areas/Topics: Biomechanical Devices ; Biomedical Engineering ; Biomedical Instruments and Devices

Abstract: In this paper, we present the design and experimental results of a multi-layered microfluidic electromagnetic cell separation device. Our channel consists of top and bottom layers in order to separate magnetically labeled cells in the vertical direction. Rapid separation of magnetic beads in top and bottom channel can be used in high throughput screening to monitor the efficacy and drug compounds. The experiments using the device were carried out with 4.5um magnetic bead and magnetic labeled Jurkat cell under electromagnetic field of 1.55mT. Without the magnetic field, the magnetic labeled cells started to flow from the bottom inlet and exit out of the bottom channel outlet. In the presence of the magnetic field, the cells started in bottom channel are attracted upward by the electromagnetic field and flow through the top layered. Finally, the labeled cells flow out the top channel outlet. The separation efficiencies of the multi-layer structured microfluidic channel showed more than 95%. We found that the multi-layer structured microfluidic channel was very effective in enhancing the separation. This microfluidic channel can be potentially applied to Lab-on-a-chip system because of its attractive features such as high throughput, continuous sorting, simple and rapid fabrication. (More)

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Paper citation in several formats:
Lee, H.; Song, S.; Lim, H.; Kim, H.; Park, M. and Jung, H. (2009). A MULTI-LAYERED MICROFLUIDIC DEVICE FOR MAGNETOPHORETIC CELL SEPARATION. In Proceedings of the International Conference on Biomedical Electronics and Devices (BIOSTEC 2009) - BIODEVICES; ISBN 978-989-8111- 64-7; ISSN 2184-4305, SciTePress, pages 286-289. DOI: 10.5220/0001776702860289

@conference{biodevices09,
author={Hye{-}Lyn Lee. and Suk{-}Heung Song. and Hee{-}Taek Lim. and Hyung{-}Joon Kim. and Min{-}Suk Park. and Hyo{-}Il Jung.},
title={A MULTI-LAYERED MICROFLUIDIC DEVICE FOR MAGNETOPHORETIC CELL SEPARATION},
booktitle={Proceedings of the International Conference on Biomedical Electronics and Devices (BIOSTEC 2009) - BIODEVICES},
year={2009},
pages={286-289},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0001776702860289},
isbn={978-989-8111- 64-7},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the International Conference on Biomedical Electronics and Devices (BIOSTEC 2009) - BIODEVICES
TI - A MULTI-LAYERED MICROFLUIDIC DEVICE FOR MAGNETOPHORETIC CELL SEPARATION
SN - 978-989-8111- 64-7
IS - 2184-4305
AU - Lee, H.
AU - Song, S.
AU - Lim, H.
AU - Kim, H.
AU - Park, M.
AU - Jung, H.
PY - 2009
SP - 286
EP - 289
DO - 10.5220/0001776702860289
PB - SciTePress