Authors:
Ming-Hsien Tsai
1
;
Ming-Jium Shieh
1
and
Cheng-Liang Peng
2
Affiliations:
1
National Taiwan University College of Medicine, Taiwan
;
2
Institute of Nuclear Energy Research, Taiwan
Keyword(s):
SN38, Micelle, Caco2.
Related
Ontology
Subjects/Areas/Topics:
Biomaterials
;
Biomechanical Devices
;
Biomedical Engineering
;
Biomedical Instruments and Devices
;
Nanotechnologies
Abstract:
Many types of nano-sized anti-cancer agents that could increase efficacy of chemotherapeutic drugs have
been created and developed in colon cancer treatment over years. Moreover, with the intention of achieving
the ideal chemotherapeutic efficacy, nano-sized anti-cancer agents were further designed to have specific
functions, efficiently killing colon cancer cells. Our research team focused on two important functions in
designing nano-sized agents, controlled drug release and targeting functions. Thus, targeting functional
micelles which entrapped chemotherapeutic drug, 7-ethyl-10-hydroxy-camptothecin (SN38) were designed
in nano-size and possessed disulfide bonds in this study. In particular, Self-Breakable SN38-loaded micelles
(SN/38 micelles), Non-Breakable micelles SN38-loaded (NB/38 micelles) and Folate-targeting Self-
Breakable SN38-loaded micelles (FSB/38 micelles) were prepared and tested to the designed agents. The
results showed that the folate-decorated functional
micelles with disulfide bonds could be an effective
chemotherapeutic agent for colon cancer treatment.
(More)