The Association of G2677T Polymorphism in MDR1 Gene with Neutropenia Incidence in Breast Cancer Patients Treated by Doxorubicin based Chemotherapy

Siti Syarifah, Dita Hasni, Tri Widyawati, Dwi Rita Anggraini

2018

Abstract

MDR1 gene is a gene that encoded P-glycoprotein (P-gp), an active efflux pump for a variety of carcinogens and cytostatics. It has been suggested that MDR1 polymorphisms G2677T contribute to the variability of therapeutic outcome and side effects. The present study was conducted to investigate the relation of G2677T polymorphisms in MDR1 gene with neutropenia incidence in breast cancer patients treated with doxorubicin based chemotherapy. As many as 147 Indonesian women’ isolated DNA samples were amplified using the PCR method. The analysis process of G2677T polymorphism were done by using PCR-RFLP method. The frequencies of MDR1 G2677T genotype for homozygous GG, heterozygous GT and variant TT was 50 (34.01%), 78 (53.1%), and 19(12.9%) respectively. No association were found between MDR1 G2677T polymorphisms with degree of neutropenia (p > 0.05). However, there was no significant deviation of allele and genotype frequency from Hardy-Weinberg Equilibrium

Paper Citation

in Harvard Style

Syarifah S., Hasni D., Widyawati T. and Anggraini D. (2018). The Association of G2677T Polymorphism in MDR1 Gene with Neutropenia Incidence in Breast Cancer Patients Treated by Doxorubicin based Chemotherapy. In Proceedings of the 3rd International Conference of Computer, Environment, Agriculture, Social Science, Health Science, Engineering and Technology - Volume 1: ICEST, ISBN 978-989-758-496-1, pages 428-431. DOI: 10.5220/0010044204280431

in Bibtex Style

@conference{icest18,
author={Siti Syarifah and Dita Hasni and Tri Widyawati and Dwi Rita Anggraini},
title={The Association of G2677T Polymorphism in MDR1 Gene with Neutropenia Incidence in Breast Cancer Patients Treated by Doxorubicin based Chemotherapy},
booktitle={Proceedings of the 3rd International Conference of Computer, Environment, Agriculture, Social Science, Health Science, Engineering and Technology - Volume 1: ICEST,},
year={2018},
pages={428-431},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010044204280431},
isbn={978-989-758-496-1},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 3rd International Conference of Computer, Environment, Agriculture, Social Science, Health Science, Engineering and Technology - Volume 1: ICEST,
TI - The Association of G2677T Polymorphism in MDR1 Gene with Neutropenia Incidence in Breast Cancer Patients Treated by Doxorubicin based Chemotherapy
SN - 978-989-758-496-1
AU - Syarifah S.
AU - Hasni D.
AU - Widyawati T.
AU - Anggraini D.
PY - 2018
SP - 428
EP - 431
DO - 10.5220/0010044204280431