DRUG ADDICTION: A COMPUTATIONAL MULTISCALE MODEL COMBINING NEUROPSYCHOLOGY, COGNITION AND BEHAVIOR

Yariv Z. Levy, Dino Levy, Jerrold S. Meyer, Hava T. Siegelmann

2009

Abstract

According to the United Nations, approximately 24.7 million people used amphetamines, 16 million used cocaine, and 12 million used heroin in 2006/07 (Costa, 2008). Full recovery from drug addiction by chemical treatment and/or social and psychological support is uncertain. The present investigation was undertaken to expand our understanding of the factors that drive the dynamics of addiction. A new multiscale computational model is presented which integrates current theories of addiction, unlike previous models, considers addiction as a reversible process (Siegelmann, 2008). Explicit time dependency is added to the inhibition and the compulsion processes. Preliminary computational predictions of drug-seeking behavior are presented and potential correlation with experimental data is discussed. Validation of the model appears promising, however additional investigation is required.

References

  1. Ahmed, S. H., Bobashev, G., and Gutkin, B. S. (2007). The simulation of addiction: Pharmacological and neurocomputational models of drug self-administration. Drug Alcohol Depen, 90(2-3):304-311.
  2. Durston, S., Thomas, K. M., Yang, Y., Ulug, A. M., Zimmerman, R. D., and Casey, B. J. (2002). A neural basis for the development of inhibitory control. Dev Sci, 5(4):F9-F16.
  3. Erb, S., Shaham, Y., and Stewart, J. (1996). Stress reinstates cocaine-seeking behavior after prolonged extinction and a drug-free period. Psychopharmacology (Berl), 128(4):408-12.
  4. Greenbaum, P. E., Boca, F. K. D., Darkes, J., and Goldman, C.-P. W. M. S. (2005). Variation in the drinking trajectories of freshmen college students. J Consult Clin Psychol, 73(2):229-238.
  5. Hodgins, D. C., el Guebaly, N., and Armstrong, S. (1995). Prospective and retrospective reports of mood states before relapse to substance use. J Consult Clin Psychol, 63(3):400-7.
  6. Hyman, S. E. (2005). Addiction: a disease of learning and memory. Am J Psychiatry, 162(8):1414-22.
  7. Interlandi, J. (2008). What addicts need. Newsweek, March 3:36-42.
  8. Kenford, S. L., Wetter, D. W., Welsch, S. K., Smith, S. S., Fiore, M. C., and Baker, T. B. (2005). Progression of college-age cigarette samplers: What influences outcome. Addict Behav, 30(2):285-294.
  9. Koob, G. F. and Le Moal, M. (2001). Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology, 24(2):97-129.
  10. Leon-Carrion, J., Garcia-Orza, J., and Perez-Santamaria, F. J. (2004). Development of the inhibitory component of the executive functions in children and adolescents. Int J Neurosci, 114(10):1291-311.
  11. Robinson, T. E. and Berridge, K. C. (1993). The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Rev, 18(3):247-91.
  12. Robinson, T. E. and Berridge, K. C. (2003). Addiction. Annu Rev Psychol, 54:25-53.
  13. See, R. E. (2002). Neural substrates of conditioned-cued relapse to drug-seeking behavior. Pharmacol Biochem Behav, 71(3):517-29.
  14. Siegelmann, H. T. (2008). Dynamical addict: cessation, relapse, and possible recovery. Submitted.
  15. Sinha, R., Fuse, T., Aubin, L. R., and O'Malley, S. S. (2000). Psychological stress, drug-related cues and cocaine craving. Psychopharmacology (Berl), 152(2):140-8.
  16. Sobell, L. C., Ellingstad, T. P., and Sobell, M. B. (2000). Natural recovery from alcohol and drug problems: methodological review of the research with suggestions for future directions. Addiction, 95(5):749-764.
  17. Spealman, R. D., Barrett-Larimore, R. L., Rowlett, J. K., Platt, D. M., and Khroyan, T. V. (1999). Pharmacological and environmental determinants of relapse to cocaine-seeking behavior. Pharmacol Biochem Behav, 64(2):327-36.
  18. Stewart, J. (2000). Pathways to relapse: the neurobiology of drug- and stress-induced relapse to drug-taking. J Psychiatry Neurosci, 25(2):125-36.
  19. Winick, C. (1962). Maturing out of narcotic addiction. The United Nations Office on Drugs and Crime (UNODC) Bulletin on Narcotics, 1962(1):1-7.
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Paper Citation


in Harvard Style

Levy Y., Levy D., Meyer J. and T. Siegelmann H. (2009). DRUG ADDICTION: A COMPUTATIONAL MULTISCALE MODEL COMBINING NEUROPSYCHOLOGY, COGNITION AND BEHAVIOR . In Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2009) ISBN 978-989-8111-65-4, pages 87-94. DOI: 10.5220/0001539100870094


in Bibtex Style

@conference{biosignals09,
author={Yariv Z. Levy and Dino Levy and Jerrold S. Meyer and Hava T. Siegelmann},
title={DRUG ADDICTION: A COMPUTATIONAL MULTISCALE MODEL COMBINING NEUROPSYCHOLOGY, COGNITION AND BEHAVIOR},
booktitle={Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2009)},
year={2009},
pages={87-94},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0001539100870094},
isbn={978-989-8111-65-4},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2009)
TI - DRUG ADDICTION: A COMPUTATIONAL MULTISCALE MODEL COMBINING NEUROPSYCHOLOGY, COGNITION AND BEHAVIOR
SN - 978-989-8111-65-4
AU - Levy Y.
AU - Levy D.
AU - Meyer J.
AU - T. Siegelmann H.
PY - 2009
SP - 87
EP - 94
DO - 10.5220/0001539100870094