Independent Component Analysis and Raman Microspectroscopy on Paraffinised Non Dewaxed Cutaneous Biopsies: A promising Methodology for Melanoma Early Diagnosis

Cyril Gobinet, Ali Tfayli, Olivier Piot, Valeriu Vrabie, Régis Huez

Abstract

This paper deals with a promising methodology for melanoma early diagnosis. Raman spectroscopy is used to record vibrational information of paraffinised tumoral tissues. Independent Component Analysis (ICA) is performed on Raman spectra to numerically deparaffinise spectra. Resulting deparaffinised spectra are used to extract discriminant information specific to malignant and benign tumors. These spectral specificities can be employed as molecular descriptors of the type of pathology. A comparison with Principal Component Analysis (PCA) shows that ICA is more suited to process this kind of problem.

References

  1. Gniadecka, M., Wulf, H., Mortensen, N., Nielsen, O. Christensen, D.: Diagnosis of basal cell carcinoma by Raman spectra. Journal of Raman Spectroscopy, Vol. 28 (1997) 125-129
  2. Sigurdsson, S., Philipsen, P., Hanson, L., Larsen, J., Gniadecka, M., Wulf, H.: Detection of skin cancer by classification of Raman spectra. IEEE Transactions on Biomedical Engineering, Vol. 51 (2004) 1784-1793
  3. Tfayli, A., Piot, O., Durlach, A., Manfait, M.: Discriminating nevus and melanoma on paraffin embedded skin biopsies using FTIR microspectroscopy. BBA General Subjects, accepted manuscript
  4. Mazet, V., Carteret, C., Brie, D., Idier, J., Humbert, B.: Background removal from spectra by designing and minimising a non-quadratic cost function. Chemometrics and Intelligent Laboratory Systems, Vol. 76 (2005) 121-133
  5. Vrabie, V., Le Bihan, N., Mars, J.: 3D-SVD and partial ICA for 3D array sensors. In: 72nd International Conference of the Society of Exploration Geophysicists (SEG'2002). Salk Lake City, USA.
  6. Comon, P.: Independent component analysis: a new concept?. Signal Processing, Vol. 36 (1994) 287-314
  7. Cardoso, J.-F., Souloumiac, A.: Blind beamforming for non-Gaussian signals. IEE Proceedings F, Vol. 140 (1993) 362-370
  8. De Lathauwer, L., De Moor, B., Vanderwalle, J.: Fetal electrocardiogram extraction by blind source subspace separation. IEEE Transactions on Biomedical Engineering, Vol. 47 (2000) 567-572
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Paper Citation


in Harvard Style

Gobinet C., Tfayli A., Piot O., Vrabie V. and Huez R. (2005). Independent Component Analysis and Raman Microspectroscopy on Paraffinised Non Dewaxed Cutaneous Biopsies: A promising Methodology for Melanoma Early Diagnosis . In Proceedings of the 1st International Workshop on Biosignal Processing and Classification - Volume 1: BPC, (ICINCO 2005) ISBN 972-8865-35-X, pages 19-26. DOI: 10.5220/0001195500190026


in Bibtex Style

@conference{bpc05,
author={Cyril Gobinet and Ali Tfayli and Olivier Piot and Valeriu Vrabie and Régis Huez},
title={Independent Component Analysis and Raman Microspectroscopy on Paraffinised Non Dewaxed Cutaneous Biopsies: A promising Methodology for Melanoma Early Diagnosis},
booktitle={Proceedings of the 1st International Workshop on Biosignal Processing and Classification - Volume 1: BPC, (ICINCO 2005)},
year={2005},
pages={19-26},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0001195500190026},
isbn={972-8865-35-X},
}


in EndNote Style

TY - CONF
JO - Proceedings of the 1st International Workshop on Biosignal Processing and Classification - Volume 1: BPC, (ICINCO 2005)
TI - Independent Component Analysis and Raman Microspectroscopy on Paraffinised Non Dewaxed Cutaneous Biopsies: A promising Methodology for Melanoma Early Diagnosis
SN - 972-8865-35-X
AU - Gobinet C.
AU - Tfayli A.
AU - Piot O.
AU - Vrabie V.
AU - Huez R.
PY - 2005
SP - 19
EP - 26
DO - 10.5220/0001195500190026