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Authors: Howard Clyde Wikle III ; Suiqiong Li ; Aleksandr Simonian and Bryan A. Chin

Affiliation: Auburn University, United States

ISBN: 978-989-8425-91-1

Keyword(s): Pathogen Detection, Biosensor, Bio-inspired, Phage, Magnetoelastic, Wireless Sensor.

Related Ontology Subjects/Areas/Topics: Biomechanical Devices ; Biomedical Engineering ; Biomedical Instruments and Devices ; Biomedical Sensors ; Devices ; Health Monitoring Devices ; Human-Computer Interaction ; Physiological Computing Systems ; Wireless Systems

Abstract: This paper describes the results of a research project to investigate and develop an autonomous pathogen detection and capture system that mimics the function of naturally occurring biological defensive systems, such as white blood cells. The autonomous sentinel system is envisioned to have the capability of seeking out invasive pathogens in liquid environments, detecting and capturing them. Once detected and captured the invasive pathogens can be removed, by retrieving the sentinels using a magnetic field. The sentinels are composed of two main parts: a magnetoelastic resonator whose motion and detection functions is actuated and monitored using magnetic fields; and a bio-probe that is immobilized onto the resonator surface and captures specific target pathogens. The freestanding sentinels require no on-board power for motion or to signal detection of a target pathogen. Upon contact with the target pathogen, the bio-molecular recognition element on the sentinel will bind with the tar get cell. This will cause a mass change of the sentinel, which results in a change in the sentinel's resonant frequency and the instantaneous detection of the target pathogen. Similar to white blood cells, the autonomous sentinels when placed in a liquid analyte will move through the analyte, capture and disable the target pathogens and signal their detection. The objective of this paper is to demonstrate proof-in-principal of the concept of autonomous sentinels. (More)

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Paper citation in several formats:
Wikle III H., Li S., Simonian A. and A. Chin B. (2012). AUTONOMOUS SENTINELS FOR THE DETECTION OF INVASIVE PATHOGENS.In Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2012) ISBN 978-989-8425-91-1, pages 47-52. DOI: 10.5220/0003775200470052

@conference{biodevices12,
author={Howard Clyde Wikle III and Suiqiong Li and Aleksandr Simonian and Bryan A. Chin},
title={AUTONOMOUS SENTINELS FOR THE DETECTION OF INVASIVE PATHOGENS},
booktitle={Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2012)},
year={2012},
pages={47-52},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0003775200470052},
isbn={978-989-8425-91-1},
}

TY - CONF

JO - Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2012)
TI - AUTONOMOUS SENTINELS FOR THE DETECTION OF INVASIVE PATHOGENS
SN - 978-989-8425-91-1
AU - Wikle III H.
AU - Li S.
AU - Simonian A.
AU - A. Chin B.
PY - 2012
SP - 47
EP - 52
DO - 10.5220/0003775200470052

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